Environmental Impact on Reproductive Health & Early Development

The Environmental Impact on Reproductive Health & Early Development (eLIFE) Research Interest Group is focused on reproductive health and the developmental origins of health and disease (DOHaD). The DOHaD paradigm postulates that exposures during vulnerable windows of fetal development impact adult-onset diseases. In eLIFE, we aim to advance our understanding of how the timing of toxicant exposures, either as single chemicals or mixtures of chemicals, of both male and female partners can affect various health outcomes including reproductive success, early embryo development, and the health trajectory of offspring. Through strong study design, excellent exposure measurement, and cutting-edge statistics and computational techniques of a broad range of omics data, we can begin to understand these complex exposure-health relationships and use this information to design disease prevention approaches.


Name Research Interests
J. Richard Pilsner (Leader) Sperm epigenetics; biomarkers of reproductive success; endocrine-disrupting chemicals
Andrea Cassidy-Bushrow Psycho-biological determinants of birth outcomes; racial disparities; epidemiology
Alan Dombkowski Functional genomics and bioinformatics
Stephen Krawetz Male contribution to reproductive success; sperm RNAs
Francesca Luca Genetic and molecular basis of inter-individual differences in pediatric asthma
Gil Mor Maternal and fetal components of pregnancy; immunology; preterm birth
Roger Pique-Regi Computational/bioinformatic methods and statistical models of large genomics datasets
Jayanth Ramadoss Perinatal and obstetric medicine; alcohol exposure; e-cigarette vaping
Daniel Rappolee Environmental factor effects on embryonic development
Douglas Ruden Early-life exposures on epigenetics dysregulation
Jennifer Straughen Prenatal exposures and pregnancy outcomes; epidemiology; role of placenta


Research Highlights

Mor/Ruden/Ramadoss (other non-elife CURES members: Stemmer/Petriello/Sadagurski),Maxwell, A., Adzibolosu. N., Hu, A., You Y., Stemmer, P.M., Ruden, D.M., Petriello, M.C., Sadagurski, M., Debarba, L.K., Koshko, L., Ramadoss, J., Nguyen, A., Richards, D., Liao, A., Mor, G., Ding, J., Intrinsic Sexual Dimorphism in the Placenta Determines the Differential Response to Benzene Exposure. iScience 26, 106287 21, 2023.

Pilsner Highlights:

  1. Invited speaker at the NIH Workshop on Multigenerational Nutrition and Influences on Health and Disease.  https://www.scgcorp.com/nutrition-wksh-2023/
  2. Pilsner’s research featured in June 2023 NIEHS newsletter, Environmental Factor.  https://factor.niehs.nih.gov/2023/6/feature/3-mens-reproductive-epigenetics?utm_medium=email&utm_source=govdelivery


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Center for Urban Responses to Environmental Stressors