Contact: Todd Lydic, CURES member

The Molecular Metabolism and Disease Mass Spectrometry Core at Michigan State University (MMDMSC) led by Dr. Todd Lydic has been recruited by the CURES ESFC to provide lipidomic analysis. CURES investigators now have access to 11 untargeted shotgun MS/MS approaches to quantify several hundred to a few thousand lipids as potential novel exposure signatures. This is an extremely innovative and powerful approach to exposome analysis that will be increasingly important as environmental health research incorporates nonchemical stressors into models of toxicity and health effects of chemical exposures. Also, by utilizing Orbitrap MS systems and MSn capability in the same analytical run for in-depth structural elucidation, the ESFC can significantly reduce the required sample size and analytical time for deep lipidomic profiling. The use of high-resolution/accurate-mass MS for lipid and metabolite feature detection enables virtually endless mining of acquired MS datasets by accurate mass-based searches of multiple databases as new compounds of interest are identified.

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