Exposure Signatures Facility Core (ESFC)
The Exposure Signatures Facility Core (ESFC) measures toxicants and the biological consequences of exposure to toxicants for individuals and in real-world samples from our environment. The goal is to integrate measurements of the amount of toxicant exposure with measurements of gene expression, protein abundance or signaling molecule status that indicate the impact of exposure in the individual. The integration of exposure data and exposure signatures that are determined by the biological response to the toxicant, inform investigators about the origin(s) of environmentally-linked diseases.
The ESFC is a collaborative effort of six analytical laboratories that each contribute unique capabilities to identifying and quantifying toxicants and biological responses to toxicant exposure. High performance omics technologies including epigenomic, transcriptomic, and proteomic analyses are most frequently requested by CURES Center investigators and form the base for the services offered by the ESFC. With investigators increasingly focused on questions regarding the interaction of environmental exposure and the physiological response to chemical and non-chemical stressors we have expanded our analytical capabilities to include protein and DNA adducts, small molecule toxicants and metabolites, cellular profiling, cytokines and lipids. Our combined laboratories offer some of the most advanced analytical capabilities available for targeted and untargeted analysis of the exposome and identification of exposure signatures. Although we focus on the common matrices of blood, plasma and urine, we can work with any biological or environmental sample matrix. Because few investigators are completely familiar with the full scope and power of the services and technologies available through the ESFC, we are available to consult with investigators when they are planning a project. The ESFC continues to work with investigators once data are obtained. The complete ESFC package provides investigators with planning, advanced analytical technology, expert technical assistance and informatics for interpretation of the results.
Susan Land, Ph.D.
Dept. Obstetrics and Gynecology, Director of Applied Genomics Technology Center (WSU)
Douglas Ruden, Ph.D.
IEHS, Director of Epigenomics, C.S. Mott Center for Human Growth and Development, LED, (WSU)
Paul Stemmer, Ph.D.
IEHS, Director of Proteomics Core Facility, EMI, (WSU)
Integrative Health Sciences Facility Core (IHSFC)
The integrative Health Sciences Facility Core (IHSFC) supports the efforts of researchers to understand the complex role of chemical and non-chemical stressors as modifiers of human health in an urban environment. The IHFSC facilitates transdisciplinary team-building in support of environmental disease prevention. IHSFC services are:
- Translational Study Design and Biostatics Support. The IHSFC helps researchers design translational studies that will best address community-voiced environmental health concerns. The IHSFC provides one-on-one consultations, biostatistical and study design support, and ready access to the latest environmental science technologies and research models. The core is also responsible for Center Evaluation and Continuous Improvement.
- Making Community-Researcher Connections. The IHSFC works with the CURES community Outreach and Engagement Core (COEC) to link investigators with community partners. We provide a framework of support for the bidirectional education and translation of the collaborative work undertaken in the Center.
"Rapid Response" Environmental Response Dream Teams
The IHSFC utilizes a meta-team approach to achieve translational integration across the Center. Guided by a prioritized directive of environmental health concerns from the COEC, the IHSFC recruits rapid-response “dream teams” of environmental health specialists from the Center and beyond to tough environmental health problems identified by the community. To brainstorm about the identified environmental health problem, a working group is assembled consisting of a tailored blend of transdisciplinary experts, including basic scientists, population scientists, clinicians, social scientists, urban planners, and ethics specialists.
Integrative Health Sciences Facility Core Co-Leaders
Graham Parker, Ph.D.
Dept. of Pediatrics (WSU)
Samiran Ghosh, Ph.D.
Dept. of Family Medicine and Public Health Sci. and Dept. of Molecular Medicine and Genetics (WSU)
Malcolm Cutchin, Ph.D.
Dept. of Health Care Sciences (WSU)